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1.
J Craniofac Surg ; 2024 Jan 29.
Artículo en Inglés | MEDLINE | ID: mdl-38284877

RESUMEN

The aim of this study was to evaluate the quality of the information on YouTube regarding night guards (NGs). YouTube was systematically searched using the keyword "night guards." Two independent reviewers examined the first 100 videos and exclusion criteria were applied. Descriptive characteristics of the remaining 60 videos were recorded. In addition, the purpose, target audience, and source of the included videos were collected. A 12-point content scale (CS) was used to evaluate video content, and the Global Quality Scale (GQS) was used to determine video quality. Statistical analyses were performed using the Kruskal-Wallis and Mann-Whitney tests, and the correlation between scores was evaluated using Spearman rho. Of the included videos, 50% were uploaded by dentists/health institutions, 26% by commercial sources and 24% by laypersons. The aim of 80% of the videos was to inform laypeople and 14% to inform professionals only. The content discussed the most (59.3%) was the production stages of NGs. The mean CS and GQS score of the videos were 2.06 ± 1.35 (poor) and 1.71 ± 0.88 (generally poor), respectively. A positive correlation was found between the CS and GQS scores (r = 0.447). YouTube videos were found to be poor in terms of both content and quality. Since NGs for treating bruxism will always be a trending topic for patients on social media, the content of YouTube videos should be checked and enriched by professionals so that patients can access accurate information, especially about NGs obtained over the counter.

2.
J Stomatol Oral Maxillofac Surg ; 125(3): 101724, 2023 Dec 03.
Artículo en Inglés | MEDLINE | ID: mdl-38052322

RESUMEN

OBJECTIVE: In this comprehensive evaluation, ten experienced oral surgeon experts posed a total of twenty oral surgery-related questions, including dental implant and tooth extractions, to three distinct Natural Language Processing (NLP)-based chatbot platforms: ChatGPT, Microsoft Bing, and Google Bard. The study aimed to assess the effectiveness of these chatbots in responding to specialized medical questions. MATERIALS AND METHODS: Two primary evaluation metrics were employed: a Likert Scale (LS) for measuring the accuracy and completeness of responses and a Global Quality Scale (GQS) for evaluating the clarity of responses. Statistical analyses, including one-way analysis of variance (ANOVA) and Post Hoc Tukey, were conducted to assess and compare the performance of the chatbots as rated by the experts. RESULTS: The results of the study revealed significant differences in the performance of the chatbots. ChatGPT statistically achieved a better mean LS score of 1.4000±0.15986 than Microsoft Bing (1.8750±0.18143) and Google Bards (2.0500±0.12472) (P < 0.001). Additionally, ChatGPT statistically achieved a higher GQS score of 4.4200±0.30111 than Microsoft Bing (3.7550±0.28621) and Google Bards (3.5250±0.22392) (P < 0.001). CONCLUSIONS: These findings showed the substantial advantage of ChatGPT in effectively addressing oral surgery-related questions with superior accuracy, completeness, and clarity. The study highlights the potential of advanced NLP platforms to enhance information retrieval and communication within the field of oral surgery, reinforcing the utility of such technologies in medical and surgical domains.

3.
J Craniofac Surg ; 33(7): 2100-2103, 2022 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-35258014

RESUMEN

ABSTRACT: The aim of this study is to investigate the quality of the information YouTube TM offers to patients concerning dental implant failure. YouTube TM was searched systematically using the keyword 'dental implant failure'. The first 100 videos were viewed by two independent researchers. For each video, its purpose, target audience and source were also recorded. A 10 point content scale (CS) was used to evaluate the video content. The Global Quality Scale (GQS) was also used to determine the quality of videos. Statistical analyses were performed using the Kruskal Wallis and Mann Whitney test and correlation coefficient analyses were performed using Spearman's Rho. While 92.2% of the videos included in the study were uploaded by dentists/health institutions, only 3.1% were uploaded by laypersons. Of the videos, 40.6% were aimed at informing laypersons and 56.3% targetted professionals. The content which was discussed most (71.9%) was 'definition of a dental implant' followed by 'reasons for failure' (65.6%). The mean CS and GQS score of the videos were 3.75 ± 2.35 (moderate) and 2.07 ± 1.05 (generally poor), respectively. There was a positive correlation between the CS and GQS score (r = 0.620). The quality of information on YouTube TM regarding dental implant failure was found inadequate. Thus, the information currently available online needs to be constantly checked and improved by professionals. In addition, clinicians should improve the ways in which they use YouTube TM to better inform patients about the causes, risks and treatment choices involved with failed dental implants.


Asunto(s)
Implantes Dentales , Medios de Comunicación Sociales , Humanos , Difusión de la Información , Reproducibilidad de los Resultados , Grabación en Video
4.
J Oral Maxillofac Surg ; 76(9): 1983-1990, 2018 09.
Artículo en Inglés | MEDLINE | ID: mdl-29625030

RESUMEN

PURPOSE: To evaluate the long-term postsurgical stability of counterclockwise rotation of the occlusal plane (OP) in double-jaw orthognathic surgery in patients with hyperdivergent Class III malocclusion. MATERIALS AND METHODS: This retrospective cohort study evaluated the postsurgical stability of orthognathic surgery in patients with skeletal Class III malocclusion and counterclockwise rotation of the maxillomandibular complex with an OP change of at least -2°. Patients were evaluated with lateral cephalometric analysis before surgery, immediately after surgery, and at longest follow-up. The primary predictor variable was the change in angle of the OP and the Frankfort horizontal (FH) after surgery. The primary outcome variable was stability of the OP at longest follow-up. Other study variables were age, gender, and the following cephalometric measurements: mandibular plane angle; gonial angle; angle formed by the sella, nasion, and B point; maxillary height; angle of the palatal plane to the line connecting the sella and nasion; and distances of the posterior nasal spine and A point to the FH and of the A point to the vertical line passing from the nasion. The Mann-Whitney U test was used to compare stability between groups because the variables were not normally distributed. Bonferroni correction was used to evaluate P values. The χ2 test and Fisher exact test, where appropriate, were used to compare the proportions of groups. A P value less than .05 was accepted as statistically significant. RESULTS: The sample was composed of 15 adult patients (mean age at surgery, 23.5 yr; 40% men). The median duration of follow-up was 48 months (interquartile range, 36 to 60 months). The groups had similar demographic properties and similar surgical changes. Ten patients showed very stable results with an OP-FH change no greater than 1°. Four patients showed unstable results with an OP-FH change of 2.25 ± 0.5° during the follow-up period. The change in the mandibular plane angle was notable between patients with stability and those with instability, which was the variable most affected by relapse of the OP. CONCLUSION: This study found long-term postsurgical skeletal stability of counterclockwise rotation of the OP during double-jaw orthognathic surgery in patients with high angle Class III malocclusion after a median follow-up of 48 months.


Asunto(s)
Maloclusión de Angle Clase III/cirugía , Procedimientos Quirúrgicos Ortognáticos/métodos , Cefalometría , Femenino , Humanos , Masculino , Mandíbula/cirugía , Maxilar/cirugía , Estudios Retrospectivos , Rotación , Resultado del Tratamiento , Adulto Joven
5.
J Craniofac Surg ; 28(7): e657-e661, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-28857982

RESUMEN

The aim of this clinical study was to compare the influence of 2 different suturing techniques on postoperative complications and wound healing after surgical extractions of impacted mandibular third molars. In this randomized split mouth study, 30 patients were examined in whom 60 consecutive surgical extractions of symmetrically positioned impacted mandibular third molars were performed. After the extractions, the surgical flaps were sutured with either the simple interrupted or horizontal mattress suturing technique. Postoperative swelling and trismus were recorded on the 2nd, 7th, and 10th days. Pain was recorded in a 7-day diary and wound dehiscence was recorded on the10th postoperative day. Statistical evaluation of data was made using Mann-Whitney U test and Pearson correlation. There were no statistical differences between the 2 suturing techniques in terms of postoperative pain, trismus, and swelling (P > 0.05). There was significantly less wound dehiscence in the horizontal mattress suturing group than in the simple interrupted suturing group (P: 0017). According to the results of this study, the horizontal mattress suturing technique is more effective than the simple interrupted suturing technique on wound healing after impacted mandibular third molar surgery, although it does not decrease the levels of pain, trismus, and swelling.


Asunto(s)
Complicaciones Posoperatorias/epidemiología , Técnicas de Sutura , Extracción Dental/efectos adversos , Diente Impactado/cirugía , Cicatrización de Heridas/fisiología , Humanos , Tercer Molar/cirugía , Colgajos Quirúrgicos/cirugía , Técnicas de Sutura/efectos adversos , Técnicas de Sutura/estadística & datos numéricos , Suturas , Resultado del Tratamiento
6.
Pain Res Manag ; 2017: 6264146, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28757802

RESUMEN

OBJECTIVES: Nocturnal bruxism can be managed by botulinum toxin (Botox®) in patients who have not responded to conservative treatment. The aim of this study was to evaluate the efficacy of botulinum toxin A (BTXA) in the treatment of nocturnal bruxism. MATERIAL AND METHODS: The retrospective study comprised 25 female patients, aged 23-55 years (mean 35.84 ± 8.41 years). All patients received a single injection of BTXA in the right and left masseters. Evaluation was made by Visual Analogue Scale (VAS) values, complaint duration, onset of effect, and duration of effectiveness. RESULTS: BTXA produced significant improvements in pain scores. Only 2 adverse events (8%) were recorded. CONCLUSION: BTX-A is effective in the treatment of nocturnal bruxism.


Asunto(s)
Toxinas Botulínicas/uso terapéutico , Fármacos Neuromusculares/uso terapéutico , Dolor/tratamiento farmacológico , Bruxismo del Sueño/tratamiento farmacológico , Adulto , Femenino , Humanos , Persona de Mediana Edad , Dimensión del Dolor/métodos , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
7.
Exp Ther Med ; 13(5): 1827-1831, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28565774

RESUMEN

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.

8.
Lasers Med Sci ; 32(3): 673-677, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-28190112

RESUMEN

Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-ß), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-ß, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.


Asunto(s)
Rayos Láser , Ozono/uso terapéutico , Estomatitis/tratamiento farmacológico , Estomatitis/radioterapia , Animales , Modelos Animales de Enfermedad , Terapia por Luz de Baja Intensidad , Masculino , Ratas Sprague-Dawley , Cicatrización de Heridas/efectos de la radiación
9.
Med. oral patol. oral cir. bucal (Internet) ; 22(1): e102-e107, ene. 2017. ilus, tab
Artículo en Inglés | IBECS | ID: ibc-159774

RESUMEN

BACKGROUND: To evaluate the effects of different patient education techniques on patients' anxiety levels before and after dental implant surgery. MATERIAL AND METHODS: Sixty patients were randomized into three groups; each contained 20 patients; [group 1, basic information given verbally, with details of operation and recovery; group 2 (study group), basic information given verbally with details of operative procedures and recovery, and by watching a movie on single implant surgery]; and a control group [basic information given verbally «but it was devoid of the details of the operative procedures and recovery»]. Anxiety levels were assessed using the Spielberger's State-Trait Anxiety Inventory (STAI) and Modified Dental Anxiety Scale (MDAS). Pain was assessed with a visual analog scale (VAS). RESULTS: The most significant changes were observed in the movie group (P < 0.05). Patients who were more anxious also used more analgesic medication. Linear regression analysis showed that female patients had higher levels of anxiety (P < 0.05). CONCLUSIONS: Preoperative multimedia information increases anxiety level


Asunto(s)
Humanos , Ansiedad al Tratamiento Odontológico/psicología , Implantación Dental/estadística & datos numéricos , Multimedia/estadística & datos numéricos , Factores de Riesgo , Analgésicos/uso terapéutico
10.
J Craniofac Surg ; 27(7): 1879-1883, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27763979

RESUMEN

This study aims to evaluate the possible effect of more cortical bone decortication (CBD) on guided bone augmentation. A total of 16 New Zealand rabbits and 32 titanium domes were used. No cortical bone decortication was applied to the control group and in the study groups, the cortical bones were decorticated with a round burr (Group A: 1 hole with bleeding, Group B: 5 holes with bleeding, Group C: a thin layer of compact bone was completely removed with no bleeding). Then 2 titanium domes were placed on the calvarium of each rabbit with hydroxyapatite/beta-tricalcium phosphate. After 3 months, the animals were sacrificed and specimens were sent for histological and histomorphometric analysis. Histological and histomorphometric analysis showed that bone decortication with burr significantly increased new bone regeneration in all the experimental groups compared with the control group (P <0.05). No statistically significant difference was determined between the study groups. In conclusion, CBD, which has no negative impact on surgery, has a positive effect on guided bone augmentation. However, a greater amount of CBD does not have a greater effect.


Asunto(s)
Regeneración Ósea , Hueso Cortical/cirugía , Implantes Experimentales , Osteogénesis/fisiología , Cráneo/cirugía , Titanio , Animales , Fosfatos de Calcio , Modelos Animales de Enfermedad , Conejos
11.
Arch Oral Biol ; 61: 60-5, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26513683

RESUMEN

OBJECTIVE: We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS), alone and in combination, in triggering new bone formation. STUDY DESIGN: Sixteen New Zealand white rabbits were given two calvarial defects by using a 6-mm trephine bur, then divided into four treatment groups: control, LLLT, LIPUS, and LLLT+LIPUS. The LLLT and LIPUS groups were treated three times a week for two weeks. The LLLT+LIPUS group received each treatment on the same day, 12h apart, three days a week for two weeks. The animals were sacrificed after three weeks. RESULTS: LLLT and LIPUS, alone and in combination, enhanced new bone formation in comparison to the untreated controls after three weeks (P<0.05); the combined therapy did not produce an additive effect. CONCLUSIONS: Our results demonstrate the efficacy of LLLT or LIPUS in triggering bone regeneration. Therapeutic dose and duration requires further study.


Asunto(s)
Regeneración Ósea/efectos de la radiación , Terapia por Luz de Baja Intensidad/métodos , Cráneo/cirugía , Terapia por Ultrasonido/métodos , Cicatrización de Heridas/efectos de la radiación , Animales , Conejos , Microtomografía por Rayos X
12.
Implant Dent ; 25(2): 214-21, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26579850

RESUMEN

INTRODUCTION: The aim of this study was to evaluate retrospectively the 3-year outcome of implants placed in augmented maxillary sinuses with minimal residual alveolar bone heights (≤3 mm). MATERIALS AND METHOD: A total of 28 sinus floors were augmented with xenograft, and 58 implants were placed. The outcome measures were implant success based on implant stability and the absence of periimplantitis, and marginal and apical bone resorption on periapical radiograph and prosthesis survival. RESULTS: Fifty-seven of 58 implants with their prostheses remained functional with a success rate of 98.28%. None of the implants showed any signs of mobility or periimplantitis. Both apical and cervical bone resorption around the implants were highest by the end of the first year. CONCLUSIONS: The success rate of the implants placed with staged approach in augmented maxillary sinuses with the residual alveolar bone height of ≤3 mm was high in a 3-year term. Bio-Oss is an acceptable substitute autogenous bone and can be used as an augmentation material during the maxillary sinus lift procedure.


Asunto(s)
Implantación Dental Endoósea/métodos , Elevación del Piso del Seno Maxilar/métodos , Adulto , Anciano , Implantes Dentales , Estudios de Seguimiento , Humanos , Maxilar/diagnóstico por imagen , Persona de Mediana Edad , Oseointegración , Radiografía Dental , Adulto Joven
13.
Ther Clin Risk Manag ; 11: 1587-91, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26508868

RESUMEN

OBJECTIVES: Behçet's disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD. MATERIALS AND METHODS: The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0-5, 6-10, and >10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique. RESULTS: The mean mandibular body BMD values were 1.294±0.21 g/cm(2) in the control group and 1.216±0.22 g/cm(2) in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree. CONCLUSION: The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.

14.
J Craniofac Surg ; 26(5): e396-400, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-26167994

RESUMEN

This study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.


Asunto(s)
Láseres de Semiconductores/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Ozono/uso terapéutico , Animales , Enfermedades Óseas/tratamiento farmacológico , Enfermedades Óseas/radioterapia , Enfermedades Óseas/cirugía , Sustitutos de Huesos/uso terapéutico , Terapia Combinada , Tejido Conectivo/efectos de los fármacos , Tejido Conectivo/efectos de la radiación , Durapatita/uso terapéutico , Fémur/efectos de los fármacos , Fémur/efectos de la radiación , Fémur/cirugía , Inflamación , Terapia por Luz de Baja Intensidad/instrumentación , Masculino , Osteoblastos/efectos de los fármacos , Osteoblastos/efectos de la radiación , Osteocalcina/efectos de los fármacos , Osteocalcina/efectos de la radiación , Osteogénesis/efectos de los fármacos , Osteogénesis/efectos de la radiación , Ratas , Ratas Wistar , Factores de Tiempo , Cicatrización de Heridas/efectos de los fármacos , Cicatrización de Heridas/efectos de la radiación
15.
J Craniofac Surg ; 26(4): e297-9, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26080238

RESUMEN

Ameloblastoma, a benign neoplasm derived from odontogenic epithelium, is an aggressive and locally invasive tumor. It represents 11% of all odontogenic tumors and 1% of all oral odontogenic epithelial tumors. In this case report, a 20-month-old boy was referred to our clinic with complaint of collapse in his symphysis region of the mandible. Radiographic examination revealed unilocular radiolucency in this region. The lesion was enucleated with 1 tooth germ under general anesthesia and diagnosed as mural unicystic ameloblastoma by histopathologic examination. After the surgery, complete healing was obtained clinically and radiographically. No sign of recurrence has been seen during the follow-up period of 4.5 years. To our knowledge, this was the second youngest case of ameloblastoma in the English literature. However, it is the youngest case of ameloblastoma that occurred in an infant boy.


Asunto(s)
Ameloblastoma/cirugía , Mandíbula/cirugía , Neoplasias Mandibulares/cirugía , Ameloblastoma/diagnóstico por imagen , Humanos , Lactante , Masculino , Mandíbula/diagnóstico por imagen , Neoplasias Mandibulares/diagnóstico por imagen , Radiografía Panorámica
16.
Arch Oral Biol ; 60(4): 606-14, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25621939

RESUMEN

OBJECTIVE: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (ßTCP). DESIGN: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PRF, Straumann(®) Bone Ceramic (SBC), or PRF+SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4 (T1) and 10 at week 8 (T2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. RESULTS: Histomorphometric and micro-CT analysis showed that both PRF and SBC significantly increased bone regeneration at T1 and T2 (P<0.01). When PRF was used in combination with HA/ßTCP, a further significant increase in new bone formation was observed at T1 and T2 compared with that when PRF or SBC was used alone (P<0.01). CONCLUSIONS: PRF has a positive effect on bone formation when used alone and in combination with HA/ßTCP.


Asunto(s)
Plaquetas/fisiología , Regeneración Ósea/efectos de los fármacos , Sustitutos de Huesos/farmacología , Fibrina/farmacología , Hidroxiapatitas/farmacología , Cráneo/diagnóstico por imagen , Cráneo/cirugía , Microtomografía por Rayos X , Animales , Regeneración Ósea/fisiología , Conejos
17.
Drug Des Devel Ther ; 9: 6483-8, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26730181

RESUMEN

BACKGROUND: Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new applications have been investigated. The present study aimed to investigate the possible effectiveness of caffeic acid phenethyl ester (CAPE) on new bone formation in rat midpalatal suture after RME. MATERIALS AND METHODS: Twenty male Sprague Dawley rats were used in this study. The animals were randomly divided into two groups as control and CAPE group. In the CAPE group, CAPE was administered systemically via intraperitoneal injection. RME procedure was performed on all animals. For this purpose, the springs were placed on the maxillary incisors of rats and activated for 5 days. After then, the springs were removed and replaced with short lengths of rectangular retaining wire for consolidation period of 15 days. At the end of the study, histomorphometric analysis was carried out to assess new bone formation. RESULTS: New bone formation was significantly greater in the CAPE group than the control group (P<0.05). CAPE enhances new bone formation in midpalatal suture after RME. CONCLUSION: These results show that CAPE may decrease the time needed for retention.


Asunto(s)
Ácidos Cafeicos/farmacología , Osteogénesis/efectos de los fármacos , Técnica de Expansión Palatina , Paladar Duro/efectos de los fármacos , Alcohol Feniletílico/análogos & derivados , Animales , Ácidos Cafeicos/administración & dosificación , Inyecciones Intraperitoneales , Masculino , Paladar Duro/patología , Alcohol Feniletílico/administración & dosificación , Alcohol Feniletílico/farmacología , Ratas Sprague-Dawley , Factores de Tiempo
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